Endocrine Abstracts

72 years old patient was send to endocrinological outpatients clinic with suspect to nevroendocrine tumor (NET) with chromogranin A (CgA) level 379 μg/l (range 19.4–98.1). She described abdominal colic and diarrhoea lasting 2–3 hours after meals accompanied by dizziness, drenching sweat and lower blood pressure for the last 2 years. Comorbidities: arterial hypertension, chronic gastritis, heart failure and osteoporosis. Medications: omeprazole, losartan, pravast...

Six years after hemorrhagic fever with renal syndrome (HFRS) 73 years old man was admitted in hospital because of hyponatremia (Na 129 mmol/l) and abdominal pain. Before HFRS he was treated for pancreatitis, hypertension, ulcerative colitis and gallstones. In the year 2002 he was admitted with fiver, vomiting, diarrhoea, headache and blurred vision. Serologic immunoflourescence testing was positive for Hantaan (Puumala) virus. During the hospital course haemodialysis was neces...

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...